The Hidden Architecture of Cell Signaling
Cell-cell signaling pathways—Wnt, Notch, TGF-β, Eph-ephrin—are the communication infrastructure of multicellular life. Each pathway comprises families of receptors that cells can express in different combinations. But which combinations actually occur in nature? And do different cell types use the same pathways in the same way? These questions seem basic, but we didn’t have answers. Until now. Mining Single-Cell Atlases The explosion of single-cell RNA sequencing data created an opportunity. By integrating multiple public atlases, we could survey receptor expression across thousands of cell types from dozens of tissues. ...